Oxytocin: taking the heat
نویسنده
چکیده
Oxytocin-in-Uniject satisfied the standards of its temperature-time indicator (TTI) in severe home storage conditions, although that required resupply every 30 days-a logistically onerous programmatic standard. Possible advances include: (1) incorporating TTIs with packaged batches of less expensive and more widely used conventional vials of oxytocin; (2) using TTIs calibrated more closely to the actual temperature sensitivity of oxytocin; and (3) researching whether a lower dose of oxytocin would be equally efficacious in preventing postpartum hemorrhage.
منابع مشابه
Oxytocin is needed, but it is no magic bullet
immunization_standards/vaccine_quality/VVM_joint_statement_2007. pdf?ua=1] Accessed 15 October 2015. 22 Frost LJ, Reich M. Access: How Do Good Health Technologies Get to Poor People in Poor Countries? Chapter 7. Vaccine Vial Monitor. Cambridge, MA: Harvard Center for Population and Development Studies: Harvard University Press, 2009. 23 Mullany LC, Newton S, Afari-Asiedu S, Adiibokah E, Agyeman...
متن کاملPain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study
The hormone oxytocin has been hypothesized to influence the emotional dimension of pain. This randomized, placebo-controlled, double-blind, crossover study explored whether intranasal oxytocin and emotional context can affect heat pain perception in 30 healthy male volunteers. After receiving 36 IU oxytocin or placebo, participants underwent functional Magnetic Resonance Imaging (fMRI) during w...
متن کاملSocial stress blocks energy conservation in rats exposed to an oxytocin-injected cage mate.
We previously found stress-reduction in rats exposed to an oxytocin-injected cage-mate. Olfactory impairment and oxytocin antagonist treatment blocked the effect. Here, we investigated effects of social stress on the exposure-induced response and exposure on amygdaloid oxytocin concentrations. CT concentrations in exposed olfactorily impaired, CT antagonist-treated and saline-injected unexposed...
متن کاملOlfactory cues from an oxytocin-injected male rat can induce anti-nociception in its cagemates.
We recently demonstrated an olfactorily induced tail skin temperature drop in saline-injected rats exposed to an oxytocin-injected cagemate, an effect abolished by olfactory impairment. Treatment with oxytocin may induce both nociceptive and anti-nociceptive effects. The contrasting effects likely depend on the model and dosage used. Here we report an increased hindpaw withdrawal latency in res...
متن کاملEndometrial oxytocin binding sites in normal women and in subfertile patients.
Specific binding of oxytocin to high affinity sites in endometrial membrane preparations has previously been shown in sheep. Endometrial tissue preparations from 27 'normal' women of proven fertility were incubated with tritiated oxytocin and the existence of significant binding sites in human endometrium was shown. Furthermore, the level of binding sites underwent a cyclical variation with the...
متن کامل